Though endogenous PML has been shown not to interfere with HFV replication and latency and also not to get delocalized during infection (Regad et al., 2001; Meiering and Linial, 2003), PMLIII overexpression reportedly attenuates HFV transcription by interacting with the HFV transactivator protein Tas and hindering its binding to DNA (long-terminal repeat and internal promoter) (Regad et al., 2001). This evidence concerns the gene PML and infection.