Agreeably, knocking down expression of individual PML NB components such as PML, Daxx, and Sp100 in primary human fibroblasts showed a de-repressing effect on HCMV IE gene expression at low multiplicity of infection (Saffert and Kalejta, 2006; Tavalai et al., 2006, 2008; Woodhall et al., 2006; Adler et al., 2011). Here, SP100 is linked to infection.