ICP0 also induces the degradation of ATRX and IFI16 (Figure 3; Jurak et al., 2012; Orzalli et al., 2012, 2016; Diner et al., 2015b), but turnover of ATRX and IFI16 occurs with delayed kinetics relative to that of PML (Jurak et al., 2012; Cuchet-Lourenço et al., 2013), possibly indicating that degradation of host components occurs sequentially as infection progresses (Merkl and Knipe, 2019). Here, PML is linked to infection.