Interestingly, SIM-deficient mutants of PML and Daxx are not recruited to vDNA and are incapable of reproducing the repression of ICP0 null mutant HSV-1 viruses (Cuchet-Lourenço et al., 2011), indicating that SIM-dependent PML NB recruitment to HSV-1 DNA during the initial phase of infection is needed to create a transcriptionally repressive environment. The gene discussed is SIM2; the disease is infection.