After being transported to the nucleus during infection of terminally differentiated cells such as fibroblasts and epithelial cells, pp71 interacts with and triggers proteasomal degradation of Daxx and also displaces ATRX from the PML NB condensates (Figure 3; Hofmann et al., 2002; Saffert and Kalejta, 2006; Lukashchuk et al., 2008). Here, ATRX is linked to infection.