TP53 and Parkinson disease: In the PD cell model induced by rotenone, an inhibition of respiratory chain complex I, SIRT1 bound to H3K9 in the p53 promoter region, resulting in decreased H3K9 acetylation and increased H3K9 trimethylation, thereby inhibiting p53 gene transcription and reducing rotenone-induced apoptosis (Feng et al., 2015).