HIF1A and neoplasm: Overexpression of HIF-1α upregulates GLUTs, hexokinase isoform 2 (HK2), pyruvate kinase isoform M (PKM), and other key factors, leading to tumor aerobic glycolytic metabolism (Kato et al., 2018; Sormendi and Wielockx, 2018; Han et al., 2020).