PDGFRB and heart failure: Cardiomyocyte-specific inducible deletion of Pdgfrβ (PdgfrβNkxcre) in embryos, however, do not exhibit remarkable malformation, but when deleted in adults, the mice develop severe ventricular dilation and heart failure in response to pressure overload with a possible mechanism of impaired activation of Akt and MAPK pathways (Chintalgattu et al., 2010).