IDH2 and neoplasm: Hypoxia inducible factor-1α is a key gene for mammalian cells to adapt to hypoxia (Chandel et al., 2000; Zhang et al., 2007) and tumor cell glycolysis dependence (Zhong et al., 1999; Luo et al., 2011), and IDH2 has been found to promote Warburg effect through HIF-1α (Li J. et al., 2018).