LncRNA UCA1, which is highly expressed in bladder cancer tissues, regulates the expression of hexokinase 2 through the mammalian rapamycin protein number and the transcriptional activation factor 3/miR143 signaling pathway, and ultimately promotes the consumption of glucose and lactic acid in bladder cancer cells (Yang et al., 2013). This evidence concerns the gene HK2 and urinary bladder cancer.