Gao Z.X. et al. (2020) have revealed that miR-101-3p expression in degenerated NPCs is significantly lower than that in normal cells, and SNHG6 can suppress proliferation and promote apoptosis of NPCs by downregulating miR-101-3p expression and thus promote the occurrence of IDD. Whether miR-101-3p is implicated in the effect of BMSCs on ECM remodeling in IDD remains unknown. This study investigated the role and mechanism of BMSCs promoting ECM remodeling of degenerated NPCs via the miR-101-3p/EIF4G2 axis, which shall shed new insight into BMSC transplantation in the treatment of IDD. This evidence concerns the gene EIF4G2 and intervertebral disk degenerative disorder.