CFTR and cystic fibrosis: In the past, (meta-)proteomics approaches were used as a powerful tool to investigate the physiological alterations of lung tissues and body fluids (e.g. bronchoalveolar lavage, blood, feces, and sputum) in CF patients as well as CFTR post-translational modifications and CF biomarkers (Eiserich et al., 2012; Kamath et al., 2015; Debyser et al., 2016; Liessi et al., 2020).