H2AX and osteosarcoma: A report by (35) showed increased C-12 ion-induced cell killing and apoptosis, along with higher expression of p21 and γ-H2AX and proportions of G2/M-phase arrested cells, in KHOS-24S osteosarcoma and A-204 rhabdomyosarcoma cells pretreated with 0.5–1 μM SAHA.