MAPK3 and breast cancer: Luteolin is a natural flavonoid, significantly inhibited proliferation and suppressed the expression of p-STAT3, p-EGFR, p-Akt, and p-Erk1/2 in EGF-treated MCF-7 breast cancer cells (16), it also inhibited proliferation and Notch signaling-associated protein expression and regulated miRNAs in MDA-MB-231 human breast cancer cells (17).