CASP3 and neoplasm: In the tumor tissues of SMMC-7721-xenotransplanted BALB/c nude mice, Tf-LP-ERN strongly enhanced the expression levels of Bax, Bad, PUMA, cleaved RARP-1, cleaved caspase-3 and caspase-9, and decreased the expression level of Bcl-2 (Figure 4C).