ERN, LP-ERN and Tf-LP-ERN enhanced the expression levels of Bax, Bad, and PUMA, promoted the cleaved caspase-3, cleaved-9 and PARP-1, and reduced the expression level of Bcl-2, which induced apoptosis and thus to inhibited tumor growth in xenotransplanted BALB/c nude mice. The gene discussed is CASP3; the disease is neoplasm.