Epidermal growth factor receptor (EGFR), alpha-type platelet-derived growth factor receptor (PDGFRɑ), MGMT, and isocitrate dehydrogenase 1 (IDH1) pathways promote GBM therapeutic resistance, which is associated with or modulated by the assembly and disassembly of primary cilia (Figures 1 and 2). The gene discussed is PDGFRA; the disease is glioblastoma.