(62) have suggested a role for plasma-derived small EV PSMA3 and lncRNA PSMA3-AS1 as prognostic markers with lower levels of small-EVs PSMA3 and PSMA3-AS1 both associated with poorer PFS and OS for newly diagnosed MM patients treated with bortezomib-containing regimens. This evidence concerns the gene PSMA3 and Miyoshi myopathy.