Taking these previous results and our observations into account, we thus suggest that the differential sensitivity of MCF-7 and MDA-MB-231 to both Helle and Areno could be attributed to the inhibitive effect of both two compounds on SRC-3, although the alteration of the expression and activity of SRC-3 in breast cancer in vitro and in vivo obviously warrants further investigation to draw a solid conclusion. The gene discussed is NCOA3; the disease is breast cancer.