Most sporadic colon tumors are thought to arise via a stepwise process in which: (1) mutation of the APC colon tumor suppressor gene creates an ‘initiated’ epithelium that is predisposed to tumor formation; (2) loss of APC heterozygosity promotes the formation of an adenoma; and (3) additional mutations drive tumor progression (7, 8). This evidence concerns the gene APC and colonic neoplasm.