APC and neoplasm: Interestingly, no significant differences were identified between nonneoplastic tissues from tumor-bearing Apc+/Min-FCCC, tumor-free Apc+/Min-FCCC, and wild type animals, with minimal changes observed in cellular proliferation, transcription of select genes related to cellular stemness, EGFR signaling, and inflammation, or secretion of select cytokines indicative of an inflamed microenvironment.