Notably, in a separate study from this group, Apc+/Min-FCCC mice that did not have colon tumors at 6-8 weeks of age developed significantly fewer tumors by 20-22 weeks of age (1.8 ± 1.3 Mean ± S.D.)than animals that had a tumor at 6-8 weeks of age (6.4 ± 3.9; Mean ± S.D.; p=0.002) (4). This evidence concerns the gene APC and colonic neoplasm.