APC and colonic neoplasm: To control for this natural variation, all comparisons of these factors among different mouse groups were made using tissue from the distal colon, as this region is: 1) where >20% of colon tumors eventually form in Apc+/Min-FCCC mice (Supplemental Figure 3) can be evaluated by colonoscopy during preclinical chemo- and immunoprevention studies (4, 38, 39).