Results indicated that in all the population of patients with breast cancer in the database, decreased levels of CAV1, CAVIN1 and CAVIN2 were statistically related to poor OS of patients with breast cancer (p<0.05) (Table 2 and Figure S1), and lower expression of CAV1, CAV2, CAV3, CAVIN1, CAVIN2, and CAVIN4 were statistically related to shorter relapse-free survival (RFS) of the patients (p<0.05) (Table 2 and Figure S1). This evidence concerns the gene CAVIN4 and breast cancer.