TP53 and adenoma: However, the degree of Hp infection will not affect the incidence; (2) Hp-positive patients are prone to develop multiple polyps (n ≥ 2) and larger polyps (diameter > 10 mm); (3) Hp positivity has an impact on P53 expression in adenomas which may promote adenomas conversion to CRCs but has no effect on the formation and pathological morphology of adenomas; (4) The prevalence of CPs in Hp-positive Chinese patients aged 35-40 is significantly higher than that in other age groups, suggesting that Chinese individuals aged 35-40 with Hp positivity should undergo colonoscopy regularly.