HYAL1 and urinary bladder carcinoma: Previous studies demonstrate that the expression of wild type HYAL-1 (HYAL-1-v1) induces apoptosis via G2-M arrest in bladder cancer cells.60 However, due to adverse impact as an anti-adhesive on normal tissue, HYALs have limitations and side effects.93 Interestingly, commercial bovine testicular or bacterial HYAL act as an anti-adhesive compound on EMT-6 tumour spheroids improve the chemosensitivity by increasing the accessibility.94 In regards to drug therapeutics, HA also increase the intestinal fluid pressure and hinder the drug penetration in pancreatic ductal adenocarcinomas.