CD44 and neoplasm: The HA-PTX conjugated drug name as HYTAD1-p20 with improve solubility and biocompatibility in the bladder and other cancers.103,104 Similarly, HA-conjugated-PTX-N-hydroxysuccinimide ester (PTX-NHS) and HA-SN-38 (CPT11 (irinotecan) metabolite) used against CD44 expressing cell line (colon, breast, gastric and others) reduced tumour cell growth and metastasis.105-109