CD44 and neoplasm: This released Ca2 stimulates cytoskeleton rearrangement and eventually tumour progression.54-56 In breast tumour cells107-109, HA activation of CD44 leads to the expression of multidrug resistance gene (P-glycoprotein) and anti-apoptotic gene Bcl expression, which promotes tumour cell proliferation and survival.57-59 Apoptosis is a highly regulated mechanism of cell death characterized by morphological and biochemical changes, including various enzymes proteins that lead to cell death and maintain cell growth.60