This interruption cause alteration in CD44, triggered cancer progression pathways as well as induce apoptosis.138 The use of several peptides, The Pep-1 and BH-P, inhibit the proliferation of melanoma tumour cells in nude mice xenograft models.139 The CD44v6 isoforms identified as markers of CSCs in colon cancer. The gene discussed is CD44; the disease is neoplasm.