CD44 in inducing apoptosis and reducing cell invasion is HA MW dependable but still contradictory which show the response differ in differ tissue also along with MW.44,45 The high molecular weight HA blocked invasion and small molecular weight oligomerized HA to initiate apoptosis and via inhibition the activation of cell survival and growth pathway (AKT) in breast, colon and mammary cancer cells.46,47. Here, CD44 is linked to breast cancer.