TNF and pancreatic neoplasm: CD44v6v appearance only noticed in advanced stages of pancreatic cancer during the metastatic behaviour of cells and not visible in a benign tumour.73 Increased expression of CD44v6 in pancreatic cancer link to metastasis.74,75 The CD44v6 role in metastasis confirmed by transfection study confirms the involvement of CD44v6 in rat pancreatic adenocarcinoma.76 Various treatment against CD44v6 linked metastasis include bFGF, EGF, TNFα, and TGF-β1(growth factors and cytokines) unable to reduce the surface expression of CD44v6 receptor.