However, the recent proposed HA-CD44 induced tumour progression signaling events in cancer by Bourguignon 2019.61 The interaction and binding of HA to CD44v upregulate Ras/Cdc42/Rac1/RhoA/NFkB expression, and various cytokines production involve in tumour cell survival, growth, invasion, and migration. The gene discussed is NFKB1; the disease is neoplasm.