As in one study, the CD44s (standard isoform) aberrant expression or loss is linked to an increased risk of metastasis, as observed in malignant breast cancer.135 Along with this, CD44s indorsed invasion in breast tumour and liver metastasis.136 Amongst isoforms of CD44, CD44v (3, 6 and, 7 and 8) linked to the propagation of breast cancer.137 In lymph node metastasis, CD44v6 expression was upregulated, while both CD44v (v3 and v6) were upregulated invasive cribriform breast tumours. The gene discussed is CD44; the disease is breast carcinoma.