Besides various synthetic inhibitor, different natural potential compounds such as silibinin, zerumbone, gemini, curcumin, epigallocatechin gallate, and apigenin down-regulate the expression of CD44 isoforms.148 Silibinin bioactive component, isolated from plant Silybum marianum used in phase II clinical trials in prostate cancer and. The gene discussed is CD44; the disease is Familial prostate cancer.