AKT1: AKT serine/threonine kinase 1; ERBB3: Erb-b2 receptor tyrosine kinase 3; ESCAT: ESMO Scale for Clinical Actionability of molecular Targets; FGFR: fibroblast growth factor receptor; NSCLC: non-small-cell lung cancer; NTRK: neurotrophic tyrosine kinase; PIK3CA: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha;PTEN: phosphatase and tensin homolog. The gene discussed is ERBB3; the disease is non-small cell lung carcinoma.