SLC5A2 and type 2 diabetes mellitus: The objectives of this review article are to (1) Discuss the mechanism and pathophysiological involvement of the heart & the kidneys in T2DM and explain the inextricable interactions between them; (2) Review the pharmacokinetics & pharmacodynamics of SGLT2 inhibitors; (3) Summarize the cardiovascular and renal benefits of SGLT2 inhibitors in T2DM beyond glycemic control.