They recommended 5-ASA for any IBD severity and using oral 5-ASA to induce or maintain complete remission. Also, they recommended corticosteroids use from the beginning as first-line therapy. Corticosteroids can also be used orally or topically. In patients where 5-ASA and corticosteroids failed, they recommended that treatment can be escalated with thiopurine, anti-TNF therapy, vedolizumab, or tofacitinib. The gene discussed is TNF; the disease is inflammatory bowel disease.