CAD: coronary artery disease; HTN: hypertension, DM: diabetes mellitus, PAD: peripheral artery disease; DAPT: dual anti-platelet therapy; mRS: modified Rankin scale; NIHSS: National Institute of Health Stroke Scale; MCA: middle cerebral artery; ICA: internal carotid artery; ACA: anterior cerebral artery; ASPECTS: Alberta Stroke Programme Early Computed Tomography Score, IV: intravenous; tPA: tissue plasminogen activator, TICI: thrombolysis in cerebral infarction score; DHC: decompressive hemi-craniectomy; HC: hemorrhagic conversion; LOS: length of stay. The gene discussed is PLAT; the disease is peripheral arterial disease.