CD4 and Autoimmunity: Another fact to mention is that Åkesson et al. had shown an elevated percentage of terminally differentiated helper T cells CD4+ and a decreased amount of effector memory cytotoxic T cells, early differentiated and late differentiated CD8+ [9]. However, the authors concluded that their findings were not conclusive due to the differences with other studies in which the levels of CD4+ and CD8+ cells were positively correlated with autoimmunity and reactivity to gluten in CD [27].