The acute period of IS (Т0) was characterized by the following clinical and neurological parameters (score according to different scales): GCS — 13.9±2.1; NIHSS — 10.2±7.3; Rivermead — 3.0 [0.0; 5.5]; mRS — 4.2±0.7; IS focus volume — 9.3 [0.8; 36.0] сm3; focus localization: supratentorial (n=40) — 80.0±5.7%, subtentorial (n=10) — 20.0±5.7%; essential hypertension (n=46) — 92.0±2.8%; dyslipidemia (n=18) — 36.0±6.8%; diabetes mellitus (n=10) — 20.0±5.7%; atrial fibrillation (n=10) — 20.0±5.7; NSE level — 2.0 [1.5; 3.0] ng/ml. Here, ENO2 is linked to metabolic syndrome.