Independent high-risk factors also include the biliary etiology of acute pancreatitis and portosplenomesenteric venous thrombosis detected by CT, as well as abnormally high values of the following laboratory parameters obtained during the first 48 h: hematocrit ≥50%, urea ≥8.42 mmol/L, C-reactive protein ≥257 mg/L, and procalcitonin level ≥1.39 ng/ml. This evidence concerns the gene CRP and deep vein thrombosis.