Independent high-risk factors also include the biliary etiology of acute pancreatitis and portosplenomesenteric venous thrombosis detected by CT, as well as abnormally high values of the following laboratory parameters obtained during the first 48 h: hematocrit ≥50%, urea ≥8.42 mmol/L, C-reactive protein ≥257 mg/L, and procalcitonin level ≥1.39 ng/ml. The gene discussed is CRP; the disease is acute pancreatitis.