Cluster 1 has the maximum score 27.676, with 38 nodes and 512 edges, including known cancer-related genes, such as BUB1 (mitotic checkpoint serine/threonine-protein kinase BUB1), CDC20 (cell division cycle protein 20 homolog), and PLK1 (serine/threonine-protein kinase PLK1). The gene discussed is CDC20; the disease is cancer.