By analyzing the microarray-based profiling data of isogenic prostate cancer xenograft models published by Chen et al. [42], we found that the differentially expressed genes of hormone-sensitive PCa compared with castration-resistant PCa included BUB1B, ADCYAP1R1, HTR4, and LY6G6C, which was also proposed in our study. This evidence concerns the gene LY6G6C and Familial prostate cancer.