BUB1B and Familial prostate cancer: For example, Rajan et al. identified seven hub genes (ADAM7, fam72b, BUB1B, ccnb1, ccnb2, TTK, and cdk172) related to cell cycle in prostate biopsy tissues before and after docetaxel chemotherapy and androgen deprivation therapy in patients with advanced hormone-naive prostate cancer [18].