In conclusion, relatively high CRP/Alb ratios, fibrinogen, and distant metastasis are associated with a poor prognosis of Xp11.2 tRCC patients; among them, preoperative plasma fibrinogen, a routinely tested parameter before surgery, independently predicts the progression of Xp11.2 tRCC and may help identify patients with worse progression or death risk. The gene discussed is CRP; the disease is renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.