It has been discovered that nuclear receptors (NR) such as farnesoid X receptor (FXR), liver X receptor (LXR), pregnane X receptor (PXR), peroxisome proliferator-activated receptor (PPAR-α/γ/δ), and small heterodimer partner (SHP) can regulate bile acid homeostasis, bile synthesis and secretion, liver inflammation, regeneration, fibrosis, and tumor formation through ligands [14–16]. This evidence concerns the gene NR1I2 and neoplasm.