CXCL8 and colorectal carcinoma: In other cell lines from colorectal carcinoma, Crites et al. reported that a downregulation of ABCC7/CFTR increased the production of IL-6, IL-1β, and IL-8 in CACO2 and HT29 cells due to the activation of ERK1/2, MAPK, IκBα, and NF-κB pathways [27].