Translation of IRES-containing mRNAs, which encode anti-apoptotic proteins such as XIAP, Bcl-xL, and Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) as well as Nuclear factor erythroid 2-related factor 2 (Nrf2), are regulated by eIF5B in glioblastoma multiforme (GBM) cells (Ross et al., 2019, 2020). This evidence concerns the gene XIAP and glioblastoma.