IRS1 and Insulin resistance: Aganirsen is an antisense oligonucleotide that can inhibit keratinocyte proliferation and imiquimod induced psoriasis-like dermatitis via IRS1 Ser312 and dephosphorylation of Tyr612 in keratinocytes, upregulate the expression of IRS1 and GLUT2 proteins in the human hepatocarcinoma cell line (HepG2), and improve insulin resistance (Li et al., 2019; Xuguang et al., 2019).