PDE8B and thyroid gland disorder: The 11 selected thyroid-specific RNA transcripts (TPO, TG, GFRA2, IYD, PDE8B, WDR86, C16orf89, DGKI, DIO2, TSHR, and PAX8) were amplified from healthy volunteers (Supplementary Figure 2A) and thyroid patients (Supplementary Figure 2B).