The SOX4 gene has been identified as a critical component of the PTEN-PI3K-AKT pathway in prostate cancer (Bilir et al., 2016), and RUNX2 is a type of oncogene that unusually increases in prostate cancer cells, promoting their metastatic phenotype (Baniwal et al., 2010). Here, SOX4 is linked to Familial prostate cancer.