Three members of the miR-196 family where the resulting miR-196a-3p belongs – miR-196a-1, miR-196a-2, and miR-196b – could suppress breast cancer cell migration and metastasis by inhibiting HOXC8, which promotes tumorigenesis by regulating the expression of cadherin-11 in breast cancer (Li et al., 2010). The gene discussed is HOXC8; the disease is breast carcinoma.