SIK2 and neoplasm: Similarly, tumor suppressors miR-136, miR-383-5p, and miR-874 have been reported to conquer PTX resistance of ovarian cancer cells by silencing NOTCH3, tripartite motif containing 27 (TRIM27), and salt inducible kinase 2 (SIK2), respectively (Jeong et al., 2017; Xia et al., 2018; Jiang et al., 2019).