The ligand-receptor pairs that commonly showed such differences across the ten tumor and matched tissue types included PLAU-ITGA5, LIPH-LPAR2, SEM14G-PLXNB2, SEMABD-TYROBP, CCL2-CCR5, CCL3-CCR5, and CGN-TYROBP. The gene discussed is PLAU; the disease is neoplasm.