These results indicate that high expression of GTSE1, TROAP, IQGAP3, KIF23, HJURP, ASPM, MIKI67, KIF20A, FAM64A, and KIF2C might be unfavorable for glioma prognosis, whereas high expression of LDHD, ETNPPL, SCN2B, MRVI1, NEBL, ADARB2, FBXW4, CBX7, LYNX1, and SPOCK2 may be beneficial for the prognosis of glioma. Here, IQGAP3 is linked to central nervous system cancer.