ESPL1 and central nervous system cancer: These signaling pathways have been shown to play key roles in the biological behavior of many tumors in terms of metastasis and proliferation, indicating the potential role of ESPL1 as a new therapeutic and prognostic biomarker in glioma (Pennington et al., 2014; Wallace, 2014; Gavande et al., 2016; Ouyang et al., 2016; Christenson and Antonarakis, 2018).