TLR7 and systemic lupus erythematosus: Others frequent TLR7 SNPs were also investigated, such as the frequent intronic tag SNP, rs179012, previously associated with HIV-1 set-point viral load, especially in females (45), and a frequent functional SNP in the 3′ UTR of TLR7, rs3853839 in genetic association with the risk of developing systemic lupus erythematosus in males (46).