Because the T allele of rs179008 pQTL affects TLR7 protein expression and in turn TLR7-driven production of type I IFNs by pDCs in women, but not in men, its direct contribution on the clinical parameters of HIV-1 infection at the initial/acute phase of the disease was investigated in women (Figure 1). This evidence concerns the gene TLR7 and HIV-1 infection.