IL2RB and autoimmune disease: Another group (9) reported patients with different mutations in IL2RB. Despite a slight difference in phenotypes and severity, all patients share common manifestations, namely immunodeficiency and autoimmune diseases including enteropathy, skin abnormalities, autoimmune hemolytic anemia, hypergammaglobulinemia and high susceptibility to infections, proving the pleiotropic functions of IL-2R signaling.