In non-OA-CH, 10-8M and 10-10M SP increased the gene expression of COX2 (Figure 5E), a key mediator of pro-inflammatory pathways, and 10-8M SP increased the gene expression level of IL6 in non-OA-CH compared to control cells (Figure 5B). This evidence concerns the gene PTGS2 and cyclic hematopoiesis.