Another study analyzing the molecular IgE sensitization profile of allergic patients from the Philippines demonstrated that symptomatic allergy was caused mainly by house dust mite and pet allergens whereas grass pollen-specific IgE sensitization was mainly due to IgE to carbohydrate epitope-bearing allergens such as Phl p 4 and Cyn d 1 which did not cause allergic symptoms (17). This evidence concerns the gene IGHE and allergic disease.