In CRS, infusion of cytotoxic T-cells leads to a rampant release of cytokines like IFN-γ, GM-CSF, TNF, IL-10, and IL-6, triggering an inflammatory response characterized by tachycardia, risk for acute respiratory distress syndrome (ARDS) acute hypoxic respiratory failure, and multiorgan failure (191). The gene discussed is IL6; the disease is congenital rubella syndrome.