Such divergences in maturation may also persistent following infusion, as T-cell phenotypes from the bone marrow of multiple myeloma patients post anti-BMCA-CART demonstrated increased frequencies of CD8+ Tscm and Tcm populations vs CD4+ Tcm and Te populations, suggesting CD4 and CD8 cells may undergo divergent courses of maturation in vivo following infusion (213). This evidence concerns the gene CD8A and plasma cell myeloma.