While Addition of 1,25D3 to polyI:C-stimulated BSMCs significantly decreased TLR3 expression, in asthma (1.743 ± 0.6387-fold decrease, p < 0.05) (Figure 2A) and COPD (4.495 ± 0.6318-fold decrease, p < 0.05) (Figure 2B) as compared to control groups. The gene discussed is TLR3; the disease is chronic obstructive pulmonary disease.