BCR and Autoimmunity: This analysis included genes that may display compensatory expression such as Bim-related genes encoding BH-3 only pro-apoptotic, along with the anti-apoptotic genes of the Bcl-2 family as well as TLRs and the TLR and BCR signal mediator, Btk, which has been implicated in B cell mediated autoimmunity in mice (63).