However, Portugal et al. claimed that neither virulent L60 nor attenuated NH/P68 displayed any effect on IFN-I dependent genes such as ISG15 or PKR whereas the virulent strain affected to MxA expression and showed that phosphorylation of STAT1/2 was not affected during ASFV infection (Portugal et al., 2018). This evidence concerns the gene EIF2AK2 and infection.