In addition, the expression of endogenous ISG15 was also efficiently suppressed by infection with both NH/P68 and Arm/07/CBM/c2 ASFV strains in COS-1 cells treated with IFN-I (Figure 1C), both the unconjugated (15 kDa) and a conjugated (35 kDa) form of ISG15 (Supplementary Figure 1). The gene discussed is ISG15; the disease is infection.