While it is more often used in the diagnosis of hypercortisolism, a recent study demonstrated an added benefit of measuring salivary cortisol in response to corticotropin stimulation in particular in patients taking oral estrogens and in cases of indeterminate serum cortisol at 60 minutes, defined as values between 500 and 599 nmol/L (68). This evidence concerns the gene POMC and adrenal gland hyperfunction.