INS and obesity due to melanocortin 4 receptor deficiency: Indeed, LEAP-2 level positively correlated with BMI, and various other metabolic parameters of obesity, including body fat percentage, waist-to-hip ratio, blood glucose and triglycerides, visceral adipose tissue volume, liver lipid content, fasting insulin, and homeostatic model assessment for insulin resistance (HOMA-IR) (10, 57).