We analyzed patients' clinical characteristics, laboratory test results, and relapse information and found that the prevalence of connective tissue disease, leukocyte counts, Hcy levels, the proportion of ANA-positive patients, CSF leukocyte counts, protein concentration, IgG index, and 24h IgG synthesis rate were higher in the highly active NMOSD group than among the non-highly active NMOSD patients. The gene discussed is BTG3; the disease is connective tissue disorder.