On the other hand, risk factors related to demographics and genetics (age, ethnicity/race, sex, and APOE genotype), presentation cerebral disease burden (CSVD characteristics, CSS, previous stroke, and hematoma volume) and other biological markers such as high WBC and CRP demonstrate a significant association with the development of post-ICH CI (12, 13, 16, 18, 21, 23, 24, 27, 28, 37). This evidence concerns the gene APOE and Stroke.