(A) APOE genotype (E2/E3/E4), history of mood disorder, hypertension, ischemic heart disease, atrial fibrillation, diabetes, anxiety disorder, prior lobar ICH, prior nonlobar ICH, and prior ischemic stroke(B) Age, race (European American/African American/Asian American/Hispanic/Other), education (<10/≥10 years)(C) Antiplatelet agents, warfarin, statins, antihypertensive agents, selective serotonin reuptake inhibitors (SSRIs). The gene discussed is APOE; the disease is mood disorder.