Impairment was further linked to the severity of several cerebral small vessel disease (CSVD) markers such as, white matter hyperintensities per total brain volume (HR: 1.48), Fazekas score (HR: 1.51), number of cortical microbleeds (CMBs) ≥ 5 (HR: 2.05), white matter disease severity (HR: 1.70), and lobar CMB number (HR: 1.78) and APOE ε4 genotype (HR: 2.12) (12, 13). The gene discussed is APOE; the disease is cerebral small vessel disease.