APOE and Stroke: Cognitive impairment during the 3 month post-ICH time period was also associated with increased hematoma volume—hazard ratio [(HR) 1.52 per 10 cc increase], and APOE ε2 genotype (HR: 1.69) (13), prior history of stroke, older age, higher baseline CI, and higher SBP during the first 24 h (37).