The presence of circadian abnormalities in depression have been evidenced for a long time with alterations in depressed patients in the circadian rhythmicity of somatic functions including body temperature, blood pressure, or urine metabolite excretion; altered hormone rhythms including prolactin, cortisol, GH, thyrotropin, and melatonin; and in the diurnal fluctuation of symptoms of depression including alteration in sleep-wake cycles, timing and structure of sleep, appetite, or social rhythms (8–14, 37). The gene discussed is PRL; the disease is depressive disorder.