CHAT and early-onset autosomal dominant Alzheimer disease: This response could be important when considering the cholinergic hypothesis of Alzheimer's disease, where amyloid beta plaques cause a significant loss of cholinergic neurons in the nucleus basalis of Meynert, diminished ChAT transcription and activity, and loss of cholinergic synapses (including in the hippocampus) that correlate with impaired attention and memory in Alzheimer's disease patients [reviewed in (98)].