MAPT and Alzheimer disease: White matter hyperintensities predict an accelerated cognitive decline, increase in total cerebrospinal fluid (CSF) tau, hippocampal atrophy, and increased risk for AD (Kuller et al., 2003; Hertze et al., 2013; Bilello et al., 2015; Fiford et al., 2017; Salvadó et al., 2019).